Curing Diabetes with Stem cells: How is it performed? - GO.CARE Blog

Curing Diabetes with Stem cells: How is it performed?

Author: Jonathan Pham
Review Date: November 12, 2019 | Last Modified: November 29, 2019
Curing Diabetes with Stem cells: How is it performed?

Diabetes has been running rampant recently, with 30.3 million people affected in the US alone in 2015. As estimated by the American Diabetes Association, the number of diabetes diagnoses increases by approximately 1.5 million every year. Although it is not an acute condition, diabetes is capable of giving rise to serious complications over time – including high blood pressure, kidney failure, and vision loss.

As the disease’s popularity and social burdens keep skyrocketing, people have been crying out for an effective treatment method that can put an end to their sufferings. Recently, people are given the option of curing diabetes with stem cells, which proves to be a really promising method.

Learn about Diabetes

What is Diabetes?

Diabetes is a condition characterized by a malfunction in the body’s ability to control the levels of glucose (i.e: blood sugar). Normally, the pancreas is responsible for this regulation. When there is too much glucose in the blood, the pancreas’ beta cells will secrete a hormone called insulin, which signals body cells to absorb excess glucose and store them for future use.

When a person gets affected by diabetes, either the pancreas fails to produce enough insulin, or the body cells are incapable of properly responding to this hormone. This results in an abnormal increase in the levels of glucose in the bloodstream, hence giving rise to diabetic symptoms like weight loss, tiredness, blurred vision, and insatiable hunger.

Insulin production

Figure 1: The process of producing insulin in the pancreas

Can diabetes be cured completely?

Prior to the development of stem cell therapy, the only viable options that diabetic patients have to ease their symptoms are frequent insulin injections and islet transplantation. The former subjects them to a lifelong intake of medications. On the other hand, the latter is better, yet not completely effective. In fact, many patients still have to resort to insulin injections a few years after performing an islet transplant. Not to mention, the risk of rejection and the shortage of donor islets make the surgical treatment method even less appealing.

Often, diabetes originates from the body’s loss of control over its levels of blood sugar. Hence, the ideal treatment must be able to restore this function – in a natural way. Specifically, it should stimulate the body to regenerate lost insulin-creating beta cells, as well as prevent them from further damage. This is something that stem cells have been proven to be capable of in various clinical trials.

Curing diabetes with stem cells

What are stem cells?

Stem cells are unique cells that have the ability to endlessly self-renew themselves, as well as create new functional cells. Normally, these cells lie dormant in certain parts of the body (e.g: bone marrow, blood, adipose tissue). When the body gets injured or ill, these cells are activated to aid the self-repair and regeneration of damaged organs.

For recent decades, stem cells have been widely utilized in both the healthcare and beauty industry due to their regenerative and immunomodulatory effects. In fact, these cells have shown great potential in improving the condition of people who suffer from numerous chronic diseases – many of them used to be regarded as “incurable”. The list of conditions that stem cell therapy is useful for is humongous, including well-known diseases such as diabetes, autoimmune diseases (ALS, PLS), and heart failure.

Can stem cells be used to cure diabetes?

For years, researchers have been conducting research to determine the potential of curing diabetes with stem cells. Specifically, human cells were cultivated in the laboratory, so that scientists might observe their behavior under certain circumstances.

According to the journal Stem Cell Reports, in a study at the School of Medicine of Washington University, a research team was able to successfully differentiate (aka, transform) stem cells into beta cells that could respond properly to the body’s levels of glucose. After transplanting these cells onto a group of mice, the researchers noticed a production of insulin in the animals’ bodies, which aided in controlling their blood sugar for the following months. As stated by Prof. Jeffrey Millman, the newly created beta cells were able to react rapidly and properly to changes in the amount of glucose – just like those in a healthy person.

In 2011, Front Med magazine reported a study about the potential of curing diabetes with stem cells. This research involved 10 patients with Type 2 diabetes, whose age ranges from 45-82 years old. In the study, these patients received 3 intravenous injections of mesenchymal stem cells (MSCs) every month. Each time, they are injected with 1.35 million MSCs for every bodyweight. 3 months after the transplantation process, these people noticed a significant drop in their requirements for insulin supplements – down to 34.7IU from 63.7IU. In addition, their average levels of HbA1c (glycosylated hemoglobin) go down from 9.8% to 6.7%, and their kidney and heart functions started improving as well.

What type of stem cells are used to treat diabetes?

Stem cells for diabetes treatment can be collected from a variety of sources. Most of the time, our partners’ doctors use mesenchymal stem cells from the blood, umbilical cord, placenta, or bone marrow. These cells are induced pluripotent (iPS) – adult stem cells that are designed to mimic the differentiation properties of embryonic stem cells, without the drawback of uncontrollable multiplication and ethical issues.

The basis of curing diabetes with stem cells is these cells’ ability to regenerate beta cells. In a stem cell transplant for diabetes, iPS beta cells are either collected from a donor (allogeneic), or the patient’s own body (autologous). Autologous transplantation alleviates the risk of rejection, as the cells in use match those of the patient’s body. After the harvesting process, stem cells are processed in the laboratory to differentiate into beta cells, which are later transplanted into the patient’s body to replace dead beta cells and stimulate the production of insulin. These effects allow for a drop in the levels of blood sugar – without the need for insulin injections.

Overall, the common health improvements that most diabetic patients have observed after receiving stem cell treatment from GO.CARE’s hospitals include:

  • Normalized levels of blood glucose;
  • A better response to glucose tolerance tests;
  • Weight gain;
  • Secretion of C-peptides;
  • Better wound healing;
  • Reduced inflammation;
  • Increased energy levels.

For a full list of potential effects after curing diabetes with stem cells, please read here.

Where can I get Stem cell treatment for Diabetes?

Additional research is still being conducted to fully unveil the results of curing diabetes with stem cells. In the meantime, various clinical trials have been performed, and most of them have ended up with very positive results. In fact, GO.CARE’s medical partners have utilized stem cell therapy to treat hundreds of diabetic patients. After their treatment, many have noticed a significant improvement in their life quality.

Contact GO.CARE now via phone/ email to get a COMPLETELY FREE consultation about stem cell-based diabetes treatment. Our health consultants will study your case in order to determine the best hospital and treatment plan for you. We will do everything possible to help you have a better life!

You GO and we CARE!

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Diabetes and Stem Cell Research. https://www.diabetes.co.uk/Diabetes-And-Stem-Cell-Research.html. Accessed on November 12, 2019.

Diabetes – A closer look at stem cells. https://www.closerlookatstemcells.org/stem-cells-medicine/diabetes/. Accessed on November 12, 2019.

Could stem cells reverse diabetes? https://www.medicalnewstoday.com/articles/324282.php#1. Accessed on November 12, 2019.

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286886/. Accessed on November 12, 2019.

Stem cell therapy for diabetes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603032/. Accessed on November 12, 2019.

Stories of Hope: A Stem Cell Therapy for Diabetes. https://www.cirm.ca.gov/our-progress/stories-hope-stem-cell-therapy-diabetes. Accessed on November 12, 2019.

Diabetes Stem Cell Treatments. https://www.stemcells21.com/conditions-treated/diabetes-stem-cell-treatment/. Accessed on November 12, 2019.

Type 2 Diabetes & Stem cells. http://www.bangkokregenerative.com/type-2-diabetes/. Accessed on November 12, 2019.

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